Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model

Retrovirology

Table 1 Parameters values and derived quantities for the humanized mouse experiments by the Bayesian inference

Strain [best fit value (95 % CI)]	\( T\left( 0 \right) \) (cells/ml)	\( V\left( 0 \right) \) (RNA copies/ml)	\( \beta \) [(virion/ml)⁻¹ day⁻¹ (×10⁻⁷)]	\( \delta \) (day⁻¹)	\( r \) ^† [(cell/ml)⁻¹ day⁻¹ (×10⁻⁶)]	\( R_{0} \) ^‡ (–)
WT HIV-1	84,621 (66,301–105,897)	1324 (925–1837)	4.41 (2.58–6.78)	0.428 (0.261–0.699)	11.50 (7.79–16.84)	2.29 (1.75–2.90)
HIV-1Δvpu	84,621 (66,301–105,897)	1324 (925–1837)	4.41 (2.58–6.78)	0.428 (0.261–0.699)	9.97 (6.59–15.06)	1.97 (1.58–2.44)

^† \( p = 0.138 \) by the repeated bootstrap t test and Cohen’s \( d = 0.664 \) (statistical power \( = 0.290 \)) between WT HIV-1 and HIV-1Δvpu. 10 parameter sets are sampled from the posterior predictive distribution
^‡ \( p = 0.035 \) by the repeated bootstrap t test and Cohen’s \( d = 1.395 \) (statistical power \( = 0.839 \)) between WT HIV-1 and HIV-1Δvpu. 10 parameter sets are sampled from the posterior predictive distribution

ISSN: 1742-4690