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Fig. 2 | Retrovirology

Fig. 2

From: Intradermal injection of a Tat Oyi-based therapeutic HIV vaccine reduces of 1.5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial

Fig. 2

Design of the study and HIV RNA Rebound. HIV-1 infected volunteers (n = 46) were randomized into four groups having at month 0 (M0), M1 and M2 double blinded intradermal injections with respectively 0 (n = 12-black square), 11 µg (n = 12-black circle), 33 µg (n = 12-white square) or 99 µg (n = 10-white circle) of a synthetic protein called Tat Oyi in a saline buffer without adjuvant. The volunteers stopped their antiviral treatment between M5 and M7. Volunteers had undetectable HIV RNA since at least 1 year before vaccination and treatment interruption. HIV RNA rebound is displayed as the median for each group on a logarithm scale. Four volunteers did not resume ART at M6 in the 33 µg group while only two volunteers resumed ART in the other groups. HIVRNA at M7 is depicted for volunteers who resumed ART at M6 (n = 36) and at M7 (n = 10)

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Retrovirology

ISSN: 1742-4690

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