Fig. 2

Cellular proteins that interact with HBZ. The three domains of sHBZ are portrayed as squares in three different colors while the cellular binding partners of HBZ are demonstrated as squircles with colors corresponding to that of AD, CD or bZIP domain of HBZ that they interact with. Cellular proteins that bind to more than one domain of HBZ are painted in multiple colors whereas those lacking such information are painted in dark grey. The major pathways that these interactions have impact on, either positive (+) or negative (−), are noted close to respective cellular proteins while more detailed description can be found in the text. Some of the interactions are not discussed in the text due to space limitations, which include 26s proteasome [93], CENP-B [94], C/EBPα [95] and IRF-1 [96]. For Foxp3, HBZ enhances transcription from the Foxp3 promoter (Treg differentiation: diff.) while it suppresses function of Foxp3 (Treg function: func.)