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Fig. 2 | Retrovirology

Fig. 2

From: Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

Fig. 2

Antiviral activities of RPV and the RPV analogs against well-characterized NNRTI resistant mutants. The IC50 values of RPV and the RPV analogs were determined using a vector that carries WT RT and several well-known NNRTI resistant mutants in a single round infection assay. Error bars represent thestandard deviations of independent experiments, n = 4. The IC50 values of the graph are at a maximum value of 100 nM and the IC50 value of 26 against the M230L and L100I/K103N resistant mutants was beyond the point of detection in our single round infection assay, >100 nM. To better illustrate the lower IC50 values, the Y-axis is broken from 20 to 40 nM and also shown in the corresponding bars

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