Table 1 Neutralization sensitivity of transmitted/founder P08 and P11 pseudoviruses to various bnAbs
Antibody | Epitope | IC50 (µg/ml) | |
|---|---|---|---|
P08-gp160 | P11-gp160 | ||
PG9 | V1V2 | 0.690 | 1.916 |
PG16 | V1V2 | ND | ND |
PGT121 | Glycan-V3 | ND | ND |
PGT128 | Glycan-V3 | 0.011 | 0.015 |
PGT135 | Glycan-V3 | ND | ND |
2G12 | Glycan | ND | ND |
b12 | CD4bs | ND | ND |
VRC01 | CD4bs | 8.306 | 6.808 |
Ibalizumab | CD4 | 0.027 | 0.022 |
2F5 | MPER | 0.415 | 2.17 |
4E10 | MPER | 0.571 | 0.568 |
10E8 | MPER | 0.131 | 0.217 |