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Table 3 Differences between various amino acid sequences or LTR sequences derived from virulent and avirulent EIAV and in vivo and cell culture derived EIAV

From: Genetic Evolution during the development of an attenuated EIAV vaccine

  Virulenta Avirulentb p Vivoc Vitrod p e
Gag 100A/T 19 (31) 25 (36) <0.01 0 (8) 45 (49) <0.01
103T/S 14 (31) 24 (26) <0.01 0 (8) 41 (49) <0.01
447N/D 12 (31) 16 (26) >0.05 0 (8) 28 (49) <0.01
484D/N 0 (31) 17 (26) <0.01 0 (8) 19 (49) >0.05
Pol 16K/E 16 (28) 26 (26) <0.01 0 (8) 19 (47) >0.05
27E/G 10 (28) 17 (26) 0.05 < p < 0.01 0 (7) 42 (47) <0.01
64G/E 0 (28) 20 (26) <0.01 0 (7) 27 (47) 0.05 < p < 0.01
598K/R 6 (28) 26 (26) <0.01 0 (7) 20 (47) >0.05
619N/D 1 (28) 15 (26) <0.01 0 (7) 23 (47) 0.05 < p < 0.01
820I/M 0 (28) 17 (26) <0.01 0 (7) 16 (47) >0.05
gp90 46A/E 28 (65) 48 (48) <0.01 0 (35) 76 (78) <0.01
98G/R 29 (65) 45 (48) <0.01 0 (35) 75 (78) <0.01
100K/(H)Q 46 (65) 48 (48) <0.01 16 (35) 78 (78) <0.01
103H/Y 30 (65) 45 (48) <0.01 0 (35) 75 (78) <0.01
180E/K 1 (65) 22 (48) <0.01 1 (35) 22 (78) <0.01
189K/E 27 (65) 46 (48) <0.01 0 (35) 73 (78) <0.01
190E/K 27 (65) 48 (48) <0.01 0 (35) 74 (78) <0.01
193S/N 31 (65) 48 (48) <0.01 1 (35) 78 (78) <0.01
236D/-(N) 9 (65) 45 (48) <0.01 0 (35) 54 (78) <0.01
237N/K 0 (65) 36 (48) <0.01 0 (35) 67 (78) <0.01
246N/K 5 (65) 29 (48) <0.01 0 (35) 33 (78) <0.01
247E/K 4 (65) 24 (48) <0.01 0 (35) 28 (78) <0.01
321K/E(N) 31 (65) 48 (48) <0.01 1 (35) 78 (78) <0.01
410H/Q 19 (65) 37 (48) <0.01 0 (35) 56 (78) <0.01
gp45 58V(I)/T 5 (32) 15 (23) <0.01 0 (10) 26 (45) >0.05
Tat 7R/H 14 (34) 29 (29) <0.01 0 (10) 43 (53) <0.01
S2 41T/I 16 (34) 28 (30) <0.01 0 (10) 44 (54) <0.01
51T/I 15 (34) 28 (30) <0.01 0 (10) 41 (54) <0.01
55Q/K 18 (34) 30 (30) <0.01 0 (10) 46 (54) <0.01
Rev 74V/I 2 (35) 19 (27) <0.01 0 (10) 21 (52) <0.01
LTR AP-1 4 (77) 57 (65) <0.01 0 (38) 61 (104) <0.01
MDBP 14 (77) 33 (65) <0.01 1 (38) 46 (104) <0.01
E_box 30 (77) 56 (65) <0.01 0 (38) 86 (104) <0.01
  1. aVirulent strains including EIAVLN40, EIAVDV117, EIAVDLV34, and EIAVDLV62
  2. bAvirulent strains including EIAV DLV92, EIAVDLV121, and EIAVFDDV13
  3. cIn vivo strains including EIAVLN40 and EIAVDV117
  4. dEx vivo strains including EIAVDLV34, EIAVDLV62, EIAV DLV92, EIAVDLV121, and EIAVFDDV13
  5. eDetermined by the Chi square test of the SAS 9.2