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Table 3 Differences between various amino acid sequences or LTR sequences derived from virulent and avirulent EIAV and in vivo and cell culture derived EIAV

From: Genetic Evolution during the development of an attenuated EIAV vaccine

 

Virulenta

Avirulentb

p

Vivoc

Vitrod

p e

Gag

100A/T

19 (31)

25 (36)

<0.01

0 (8)

45 (49)

<0.01

103T/S

14 (31)

24 (26)

<0.01

0 (8)

41 (49)

<0.01

447N/D

12 (31)

16 (26)

>0.05

0 (8)

28 (49)

<0.01

484D/N

0 (31)

17 (26)

<0.01

0 (8)

19 (49)

>0.05

Pol

16K/E

16 (28)

26 (26)

<0.01

0 (8)

19 (47)

>0.05

27E/G

10 (28)

17 (26)

0.05 < p < 0.01

0 (7)

42 (47)

<0.01

64G/E

0 (28)

20 (26)

<0.01

0 (7)

27 (47)

0.05 < p < 0.01

598K/R

6 (28)

26 (26)

<0.01

0 (7)

20 (47)

>0.05

619N/D

1 (28)

15 (26)

<0.01

0 (7)

23 (47)

0.05 < p < 0.01

820I/M

0 (28)

17 (26)

<0.01

0 (7)

16 (47)

>0.05

gp90

46A/E

28 (65)

48 (48)

<0.01

0 (35)

76 (78)

<0.01

98G/R

29 (65)

45 (48)

<0.01

0 (35)

75 (78)

<0.01

100K/(H)Q

46 (65)

48 (48)

<0.01

16 (35)

78 (78)

<0.01

103H/Y

30 (65)

45 (48)

<0.01

0 (35)

75 (78)

<0.01

180E/K

1 (65)

22 (48)

<0.01

1 (35)

22 (78)

<0.01

189K/E

27 (65)

46 (48)

<0.01

0 (35)

73 (78)

<0.01

190E/K

27 (65)

48 (48)

<0.01

0 (35)

74 (78)

<0.01

193S/N

31 (65)

48 (48)

<0.01

1 (35)

78 (78)

<0.01

236D/-(N)

9 (65)

45 (48)

<0.01

0 (35)

54 (78)

<0.01

237N/K

0 (65)

36 (48)

<0.01

0 (35)

67 (78)

<0.01

246N/K

5 (65)

29 (48)

<0.01

0 (35)

33 (78)

<0.01

247E/K

4 (65)

24 (48)

<0.01

0 (35)

28 (78)

<0.01

321K/E(N)

31 (65)

48 (48)

<0.01

1 (35)

78 (78)

<0.01

410H/Q

19 (65)

37 (48)

<0.01

0 (35)

56 (78)

<0.01

gp45

58V(I)/T

5 (32)

15 (23)

<0.01

0 (10)

26 (45)

>0.05

Tat

7R/H

14 (34)

29 (29)

<0.01

0 (10)

43 (53)

<0.01

S2

41T/I

16 (34)

28 (30)

<0.01

0 (10)

44 (54)

<0.01

51T/I

15 (34)

28 (30)

<0.01

0 (10)

41 (54)

<0.01

55Q/K

18 (34)

30 (30)

<0.01

0 (10)

46 (54)

<0.01

Rev

74V/I

2 (35)

19 (27)

<0.01

0 (10)

21 (52)

<0.01

LTR

AP-1

4 (77)

57 (65)

<0.01

0 (38)

61 (104)

<0.01

MDBP

14 (77)

33 (65)

<0.01

1 (38)

46 (104)

<0.01

E_box

30 (77)

56 (65)

<0.01

0 (38)

86 (104)

<0.01

  1. aVirulent strains including EIAVLN40, EIAVDV117, EIAVDLV34, and EIAVDLV62
  2. bAvirulent strains including EIAV DLV92, EIAVDLV121, and EIAVFDDV13
  3. cIn vivo strains including EIAVLN40 and EIAVDV117
  4. dEx vivo strains including EIAVDLV34, EIAVDLV62, EIAV DLV92, EIAVDLV121, and EIAVFDDV13
  5. eDetermined by the Chi square test of the SAS 9.2