Rapid dissemination of human T-lymphotropic virus type 1 during primary infection in transplant recipients

Retrovirology

Table 1 Clinical details of transplant recipients

	Case 1	Case 2	Case 3
Primary organ pathology	Alcoholic liver disease	Tubulo-interstitial nephritis with focal sclerosis	End stage renal failure of unknown aetiology (diabetes/hypertension)
Age at transplantation (years)	58	48	57
Ethnicity	Caucasian	Black Caribbean	Indian
Organ transplanted	Liver	Kidney	Kidney
Class 1 HLA type	A01, A24, B08, B15, C03, C07 DR1, DR3 DQ2, DQ5	A3, A34, B51, B71, Cw3, Cw16, DR13, DQ7	A3, A24; B52, B55; Cw1, Cw12; DR10 DR14; DQ5
Peri-operative immune suppression	Basiliximab Methylprednisolone	Basiliximab Methylprednisolone	Basiliximab Mycophenolate, Tacrolimus
Post operative immune suppression	Mycophenolate, tacrolimus	None	Tacrolimus, prednisolone
Day post transplant antiretrovirals commenced	Day 19	Day 17	Day 26
Dose of antiretrovirals	Zidovudine 250 mg bd Raltegravir 400 mg bd	Zidovudine 100 mg tds Raltegravir 400 mg bd	Zidovudine 100 mg tds Raltegravir 400 mg bd
Day antiretrovirals stopped	Day 66	Day 43	Day 80
Day organ removed	Not applicable	Day 0	Day 48
Indication for organ removal	Not applicable	Life-threatening intra-operative haemorrhage	Rejection/failure

ISSN: 1742-4690