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Table 1 Synergy indices for combinations of latency reversing agents

From: HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

  No RAL +RAL
Bryostatin
 +TSA 1.06 ± 0.13 1.49 ± 0.28
 +SAHA 0.94 ± 0.07 1.09 ± 0.05
 +Scriptaid 0.95 ± 0.05 1.19 ± 0.09
 +JQ1 0.85 ± 0.06 1.14 ± 0.10
 +HMBA 0.92 ± 0.13 1.12 ± 0.16
 +Disulfiram 0.83 ± 0.06 0.79 ± 0.03
Prostratin
 +TSA 1.02 ± 0.04 1.44 ± 0.14
 +SAHA 0.96 ± 0.08 1.30 ± 0.19
 +Scriptaid 0.97 ± 0.05 1.42 ± 0.18
 +JQ1 0.87 ± 0.07 1.19 ± 0.16
 +HMBA 0.63 ± 0.10 0.77 ± 0.29
 +Disulfiram 0.55 ± 0.14 0.68 ± 0.14
JQ1   
 +TSA 0.72 ± 0.08 0.88 ± 0.22
 +SAHA 0.87 ± 0.11 0.90 ± 0.11
 +Scriptaid 0.84 ± 0.15 0.90 ± 0.10
HMBA
 +TSA 0.63 ± 0.17 0.78 ± 0.03
 +SAHA 0.62 ± 0.21 0.81 ± 0.11
 +Scriptaid 0.69 ± 0.14 0.91 ± 0.14
Disulfiram
 +TSA 0.68 ± 0.11 0.72 ± 0.13
 +SAHA 0.63 ± 0.06 0.69 ± 0.06
 +Scriptaid 0.85 ± 0.17 0.98 ± 0.19
  1. Synergy indices were calculated from 3 independent experiments with different cell donors, based on the number of GFP+ cells. Synergy was calculated according to [95] and synergy indices significantly >1 are indicated in italicized text. Additional file 1: Figure S5 contributes data for one of the 3 experiments