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Table 2 Top down regulated transcripts in CCR4+CCR6+ Th17 vs. CXCR3+CCR6− Th1
| Symbol | p | adj. p | FC | Definition |
|---|---|---|---|---|
| IL-9 | 2.7E−07 | 1.4E−04 | −46.7 | Interleukin 9 |
| GZMK | 9.7E−05 | 3.9E−03 | −17.1 | Granzyme K (granzyme 3; tryptase II) |
| IFN-γ | 8.5E−04 | 1.5E−02 | −16.7 | Interferon gamma |
| CCL5 | 3.8E−05 | 2.2E−03 | −11.9 | Chemokine (C–C motif) ligand 5 |
| GZMH | 1.4E−04 | 4.8E−03 | −11.7 | Granzyme H (cathepsin G-like 2, protein h-CCPX) |
| IL-3 | 2.2E−08 | 2.7E−05 | −11.2 | Interleukin 3 (colony-stimulating factor, multiple) |
| NKG7 | 8.4E−05 | 3.6E−03 | −9.1 | Natural killer cell group 7 sequence |
| CCL4L2 | 5.1E−03 | 4.4E−02 | −7.0 | Chemokine (C–C motif) ligand 4-like 2 |
| CCL3 | 5.3E−03 | 4.5E−02 | −6.8 | Chemokine (C–C motif) ligand 3 |
| EOMES | 2.3E−07 | 1.3E−04 | −6.6 | Eomesodermin homolog (Xenopus laevis) |
| CCL3L1 | 3.9E−03 | 3.8E−02 | −6.5 | Chemokine (C–C motif) ligand 3-like 1 |
| CCL3L3 | 5.2E−03 | 4.5E−02 | −6.3 | Chemokine (C–C motif) ligand 3-like 3 |
| NAPSB | 2.7E−03 | 3.0E−02 | −6.1 | Homo sapiens napsin B aspartic peptidase pseudogene (NAPSB) |
| BATF3 | 2.5E−08 | 2.8E−05 | −5.9 | Basic leucine zipper transcription factor, ATF-like 3 |
| NAPSA | 3.1E−04 | 7.9E−03 | −5.6 | Napsin A aspartic peptidase |
| CXCR3 | 4.2E−04 | 9.7E−03 | −5.2 | Chemokine (C–X–C motif) receptor 3 |
| MATK | 1.9E−07 | 1.2E−04 | −4.9 | Megakaryocyte-associated tyrosine kinase, transcript variant 3 |
| OSM | 2.5E−06 | 4.7E−04 | −4.3 | Oncostatin M |
| IRF8 | 2.5E−05 | 1.7E−03 | −4.2 | Interferon regulatory factor 8 |
| MAOA | 3.0E−04 | 7.8E−03 | −4.0 | Monoamine oxidase A, nuclear gene encoding mitochondrial protein |
| DNAJC12 | 5.1E−04 | 1.1E−02 | −3.9 | DnaJ (Hsp40) homolog. subfamily C, member 12 |
| MT1 J | 6.1E−06 | 7.1E−04 | −3.9 | Metallothionein 1G |
| NPSR1 | 1.5E−05 | 1.2E−03 | −3.9 | Neuropeptide S receptor 1, transcript variant 1 |
| ATP8B4 | 4.0E−05 | 2.2E−03 | −3.8 | ATPase. class I, type 8B. member 4 |
| TIMD4 | 1.8E−05 | 1.4E−03 | −3.8 | T-cell immunoglobulin and mucin domain containing 4 |
| LTA | 3.8E−05 | 2.2E−3 | −3.7 | Lymphotoxin alpha (TNF superfamily. member 1) |
| SERPINB6 | 2.1E−07 | 1.3E−04 | −3.2 | Serpin peptidase inhibitor, clade B (ovalbumin). member 6 |
| PTK2 | 5.1E−03 | 4.4E−02 | −2.7 | PTK2 protein tyrosine kinase 2, transcript variant 2 |
| CCL17 | 2.3E−05 | 1.6E−03 | −2.6 | Chemokine (C–C motif) ligand 17 |
| NFIL3 | 3.4E−03 | 3.5E−02 | −2.5 | Nuclear factor interleukin 3 regulated |
