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Fig. 6 | Retrovirology

Fig. 6

From: ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag

Fig. 6

Schematic illustration showing the mechanism by which p2 peptide positively regulates HIV-1 infection. Although the actual molecular basis of the allosteric mechanism of the p2 peptide is still unclear, the findings of this study suggest that the p2 peptide is a viral positive allosteric modulator of MT-CO1 and more efficiently supplies ATP for the active nuclear import of HIV-1 PIC. The N214–F235 domain (shown in yellow in the lower inset) was completely conserved between human and bovine MT-CO1, and the crystal structure analysis of bovine heart MT-CO demonstrated that the domain is exposed on the intermembrane space side of the inner membrane. MT-CO-1 was shown in purple inside cytochrome c oxidase

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Retrovirology

ISSN: 1742-4690

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