Retrovirology

Table 1 Associations of Gag-Pro RCs with clinical parameters in each HLA class I allele

From: Lack of a significant impact of Gag-Protease-mediated HIV-1 replication capacity on clinical parameters in treatment-naive Japanese individuals

Associations with pVL						Associations with CD4 count
HLA allele	HLA + or −^a	n	R	P value	q value	HLA allele	HLA + or −^a	n	R	P value	q value
A*02:01	+	63	0.26	0.0428	0.243	A*02:06	+	61	−0.29	0.0231	0.279
A*31:01	+	48	0.31	0.0357	0.238	B*46:01	+	31	−0.41	0.0264	0.279
B*07:02	+	24	0.46	0.0288	0.238	B*48:01	+	14	−0.65	0.0194	0.279
C08:01*	+	34	0.36	0.0377	0.238	B*59:01	+	14	−0.59	0.0344	0.318
C08:03*	+	10	0.70	0.0365	0.238	C*01:02	+	92	−0.28	0.0082	0.163
A*11:01	−	252	0.14	0.0277	0.238	C08:01*	+	34	−0.46	0.0088	0.163
A*33:03	−	265	0.14	0.0288	0.238	C08:03*	+	10	−0.69	0.0399	0.328
B*39:01	−	285	0.12	0.0385	0.238	B52:01*	−	234	−0.19	0.0045	0.163
B*44:03	−	266	0.14	0.0244	0.238	C12:02*	−	231	−0.20	0.0024	0.163
B52:01*	−	234	0.15	0.0209	0.238
C*07:02	−	233	0.14	0.0325	0.238
C12:02*	−	231	0.16	0.0135	0.238
C*14:03	−	267	0.14	0.0251	0.238

Italic HLA alleles have associations with both pVL and CD4 count
n number of subjects, R Spearman’s rank correlation
^aHLA+ and HLA− indicate subjects with or without the particular HLA allele, respectively

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ISSN: 1742-4690

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