Fig. 1

Gag-mediated replication capacities in a treatment naive Japanese cohort chronically infected with HIV-1 subtype B. a Distribution of Gag-Protease replication capacities. Recombinant HIV-1_NL4-3 was constructed, using plasma-derived gag-protease from treatment-naïve HIV⁺ Japanese patients, and replication capacity for each virus was determined by in vitro infection. The values were normalized against mean growth rate of wild-type NL4-3. The samples were measured in triplicate. b, c Replication capacities and patients’ clinical parameters. Replication capacities of chimeric viruses were plotted against plasma viral load (b) or CD4 count (c) at the time of sample collection. Correlations were determined by Spearman’s rank correlation test