Fig. 1

Whole blood BST2 mRNA levels in SIV-infected macaques. BST2 mRNA levels in whole blood of 17 rhesus macaques were determined using PAXgene Blood RNA Kit and real time PCR before and at 24 weeks after infection (wpi). a BST2 mRNA levels were compared between uninfected (circles) and SIVmac251 infected animals (squares). BST2 mRNA levels are shown in copy numbers per 100 copies of GAPDH. Horizontal lines within the clusters are depicting the median. Group comparisons were calculated using two-tailed Mann–Whitney’s U test. BST2 mRNA levels at 24 wpi (b) and BST2 mRNA levels after normalization to individual pre-infection values (c) were correlated with plasma viral load. Viral load is displayed as log-transformed RNA copies per millilitre (ml) plasma. r Spearman’s correlation coefficient; regression line is shown; p, p value. Each data point represents one individual animal