Fig. 1

Anti- HIV efficacy of a new small chemical inhibitor A1752. a The chemical structure of A1752, (Z)-3-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid. b Determination of anti-HIV activity of A1752. Inhibition of HIV-1 production in MT-4 cells infected with a HIV-1 NL4-3/EGFP in the presence of A1752 or a control inhibitor Tenofovir was determined using HIV-1 p24 ELISA. Data are the mean ± SD of triplicate experiments for each concentration. c Examination of EGFP expression as a surrogate marker for HIV-1 replication in the infected MT-4 cells treated with the inhibitors in (b) was examined on day 3 post infection. d Cellular toxicity of the A1752 was measured using a Cell-Titer Glo assay and the percentage cell survival in the presence of each indicated compound compared to that of non-treated cells. Data are the mean ± SD of three separate experiments