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Fig. 8 | Retrovirology

Fig. 8

From: Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels

Fig. 8

Age-dependent differences in CD4 and CXCR4 expression. a Representative primary data (left) for unstimulated or CD3/CD28 bead stimulated CD4+ T cells stained for CD4 or b CXCR4 expression levels. a (right) Statistical analysis of CD4 or b (right) CXCR4 expression levels on unstimulated and stimulated CD4+ T cells from young (Y) and elderly (O) donors. c Percentages and d mean fluorescence intensity (MFI) of CCR5+ within the total CD4+ T cells population in unstimulated and stimulated PBMC cultures from young (Y) and elderly (O) donors. e Correlation between CCR5 expression levels (MFI) on total CD4+ T cells and percentages of CCR5+ within total CD4+ T cells in unstimulated or stimulated PBMC cultures. f Correlation between percentages of CCR5+ within total CD4+ T cells in stimulated PBMC cultures and the cumulative levels of RT production in R5 HIV-1 NL4-3 infected PBMC cultures. Correlation between the g CD4 and h CXCR4 surface expression levels on unstimulated CD4+ T cells and the cumulative levels of RT production in X4 or R5 wild type HIV-1 NL4-3 infected PBMC cultures

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