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Fig. 6 | Retrovirology

Fig. 6

From: Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels

Fig. 6

Group-specific differences in HIV-1-infected and uninfected apoptotic T cell populations. a Flow cytometric analysis of the apoptotic lymphocyte populations in uninfected PBMC cultures and in the GFP+ and GFP− populations of cultures infected with X4 HIV-1 NL4-3 GFP reporter virus after CD3/CD28 bead stimulation from young (Y) and elderly (O) blood donors. Within the apoptotic cell population (100 %) the proportions of T cell subsets with a naïve (TN), effector memory (TEM) or central memory (TCM) phenotype were determined. b Statistical evaluation of the proportions of the indicated cell subsets within the apoptotic lymphocyte population of uninfected or X4 HIV-1 IRES-eGFP-infected PBMC cultures. c Correlation between the indicated apoptotic T cell subsets within X4 and R5 HIV-1 NL4-3 reporter virus infected PBMC cultures

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