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Table 2 pol population diversity and divergence,between plasma (week 30) and tissues at necropsy (week 30/31)

From: Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy

Tissue

Untreated

Treated

6760

8232

8272

8030

APD (%)

Panmixiaa (19 sequences)

APD (%)

Panmixiaa (17 sequences)

APD (%)

Panmixiaa (7 sequences)

APD (%)

Panmixiaa (12 sequences)

Challenge virus

0.23

<10 −6*

0.23

<10 −6*

0.23

0.59

0.23

0.04

Plasma week 1

0.28

10 −4*

0.36

<10 −6*

0.3

0.4

0.19

0.08

Plasma week 30

0.5

NA

0.19

NA

0.17

NA

0.35

NA

PBMC

0.85

0.13

0.41

0.07

0.39

0.28

0.26

0.63

Duodenum

0.3

0.002

0.09

0.06

0.32

0.05

0.14

–

Jejunum

0.43

0.07

0.4

0.48

0.41

0.37

0.37

0.3

Ileum

0.59

0.08

0.17

0.53

1.19

–

–

–

Lung

0.82

0.27

0.25

0.06

0.85

0.39

–

–

Thymus

0.46

0.001

–

–

–

–

–

–

Bone marrow

0.47

0.35

0.23

0.24

0.65

0.23

0.33

0.85

Spleen

0.61

0.0004*

0.21

0.72

0.28

0.33

0.19

0.521

Axillary LN

0.5

0.008

0.23

0.002

0.55

0.22

–

–

Mesenteric LN

0.49

0.45

0.39

0.00090*

0.64

0.02

0.24

0.64

Mean APD

0.55

0.26

0.59

0.26

  1. – Too few sequences to analyze (<7 sequences)
  2. * p value (10−3 was used as the criterion for significance due to the numbers of multiple comparisons. Significant differences indicated by bold)
  3. aProbability of panmixia of sequences in each tissue compared to an equal number of randomly selected unique sequences in the plasma
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Retrovirology

ISSN: 1742-4690

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