|
Tissue
|
Untreated
|
Treated
|
|---|
|
6760
|
8232
|
8272
|
8030
|
|---|
|
APD (%)
|
Panmixiaa (19 sequences)
|
APD (%)
|
Panmixiaa (17 sequences)
|
APD (%)
|
Panmixiaa (7 sequences)
|
APD (%)
|
Panmixiaa (12 sequences)
|
|---|
|
Challenge virus
|
0.23
|
<10
−6*
|
0.23
|
<10
−6*
|
0.23
|
0.59
|
0.23
|
0.04
|
|
Plasma week 1
|
0.28
|
10
−4*
|
0.36
|
<10
−6*
|
0.3
|
0.4
|
0.19
|
0.08
|
|
Plasma week 30
|
0.5
|
NA
|
0.19
|
NA
|
0.17
|
NA
|
0.35
|
NA
|
|
PBMC
|
0.85
|
0.13
|
0.41
|
0.07
|
0.39
|
0.28
|
0.26
|
0.63
|
|
Duodenum
|
0.3
|
0.002
|
0.09
|
0.06
|
0.32
|
0.05
|
0.14
|
–
|
|
Jejunum
|
0.43
|
0.07
|
0.4
|
0.48
|
0.41
|
0.37
|
0.37
|
0.3
|
|
Ileum
|
0.59
|
0.08
|
0.17
|
0.53
|
1.19
|
–
|
–
|
–
|
|
Lung
|
0.82
|
0.27
|
0.25
|
0.06
|
0.85
|
0.39
|
–
|
–
|
|
Thymus
|
0.46
|
0.001
|
–
|
–
|
–
|
–
|
–
|
–
|
|
Bone marrow
|
0.47
|
0.35
|
0.23
|
0.24
|
0.65
|
0.23
|
0.33
|
0.85
|
|
Spleen
|
0.61
|
0.0004*
|
0.21
|
0.72
|
0.28
|
0.33
|
0.19
|
0.521
|
|
Axillary LN
|
0.5
|
0.008
|
0.23
|
0.002
|
0.55
|
0.22
|
–
|
–
|
|
Mesenteric LN
|
0.49
|
0.45
|
0.39
|
0.00090*
|
0.64
|
0.02
|
0.24
|
0.64
|
|
Mean APD
|
0.55
|
0.26
|
0.59
|
0.26
|
- – Too few sequences to analyze (<7 sequences)
- * p value (10−3 was used as the criterion for significance due to the numbers of multiple comparisons. Significant differences indicated by bold)
-
aProbability of panmixia of sequences in each tissue compared to an equal number of randomly selected unique sequences in the plasma
