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Table 1 gag RNA and DNA copies in tissues at necropsy (week 30/31) and number of single-genome sequences obtained

From: Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy

Tissue DNA RNA
Untreated Treated Untreated Treated
EFV + FTC + TNV EFV + FTC + TNV
6760 8232 8272 8030 6760 8232 8272 8030
Copiesa # SGS Copiesa # SGS Copiesa # SGS Copiesa # SGS Copiesb # SGS Copiesb # SGS Copiesb # SGS Copiesb # SGS
Plasma – – – – – – – – 180,000c 26 8200c 44 <30c 7 <30c 16
PBMC 271 19 531 27 288 39 52 19 190 27 10 5 <1 11 30 0
Duodenum 64 24 72 33 31 42 <1 3 2040 0 <1 – <1 6 – –
Jejunum 36 24 9 29 14 24 19 25 – – 10 4 <1 0 <1 0
Ileum 330 28 205 23 32 3 <1 0 – – 270 34 – – – –
Lung 9 23 38 18 9 28 25 0 2990 4 1420 1 <1 0 <1 –
Thymus 7 28 – – – – 200 0 1370 28 – – – – 10 0
Bone marrow 25 21 2 42 4 21 2 12 180 0 10 1 <1 0 <1 0
Spleen 275 25 64 33 52 24 48 16 5670 6 460 0 <1 0 10 0
Axillary LN 833 33 86 24 171 27 32 0 15,680 22 1200 20 <1 1 <1 2
Mesenteric LN 538 27 251 22 629 23 29 23 23,490 39 130 5 <1 0 <1 0
Mean copy number 238 140 137 46 25,734 1171 <1 <9
  1. – Sample not available
  2. aRT-SHIV DNA copies per 106 cells (measured by CCR5 copy number)
  3. bRT-SHIV RNA copies per 106 CD4 RNA copies
  4. cRT-SHIV RNA copies per ml plasma
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Retrovirology

ISSN: 1742-4690

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