Retrovirology

Table 1 gag RNA and DNA copies in tissues at necropsy (week 30/31) and number of single-genome sequences obtained

From: Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy

Tissue	DNA								RNA
	Untreated				Treated				Untreated				Treated
	Untreated				EFV + FTC + TNV				Untreated				EFV + FTC + TNV
	6760		8232		8272		8030		6760		8232		8272		8030
	Copies^a	# SGS	Copies^a	# SGS	Copies^a	# SGS	Copies^a	# SGS	Copies^b	# SGS	Copies^b	# SGS	Copies^b	# SGS	Copies^b	# SGS
Plasma	–	–	–	–	–	–	–	–	180,000^c	26	8200^c	44	<30^c	7	<30^c	16
PBMC	271	19	531	27	288	39	52	19	190	27	10	5	<1	11	30	0
Duodenum	64	24	72	33	31	42	<1	3	2040	0	<1	–	<1	6	–	–
Jejunum	36	24	9	29	14	24	19	25	–	–	10	4	<1	0	<1	0
Ileum	330	28	205	23	32	3	<1	0	–	–	270	34	–	–	–	–
Lung	9	23	38	18	9	28	25	0	2990	4	1420	1	<1	0	<1	–
Thymus	7	28	–	–	–	–	200	0	1370	28	–	–	–	–	10	0
Bone marrow	25	21	2	42	4	21	2	12	180	0	10	1	<1	0	<1	0
Spleen	275	25	64	33	52	24	48	16	5670	6	460	0	<1	0	10	0
Axillary LN	833	33	86	24	171	27	32	0	15,680	22	1200	20	<1	1	<1	2
Mesenteric LN	538	27	251	22	629	23	29	23	23,490	39	130	5	<1	0	<1	0
Mean copy number	238		140		137		46		25,734		1171		<1		<9

– Sample not available
^aRT-SHIV DNA copies per 10⁶ cells (measured by CCR5 copy number)
^bRT-SHIV RNA copies per 10⁶ CD4 RNA copies
^cRT-SHIV RNA copies per ml plasma

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ISSN: 1742-4690

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