Fig. 9

Model depicting the cellular signaling pathways involved with tested Latency Reactivating Agents. SAHA, prostratin, TNF-α, PHA-M were tested in ACH-2 cells and J-Lat cell clones. αCD3/αCD28 was tested only in primary T cell model. Prostratin when tested in primary T cell model, suggested a role only for STAT and NFΚB. IΚBKB degradation leads to activation of downstream transcription regulators. Only few TFs that have binding sites on LTR corresponding to core, enhancer, modulatory and downstream regions are represented, the list of possible signaling molecules that can directly or indirectly regulate HIV-1 latency status is included in Table 2. Ac acethylation, Me methylation, HDAC histone deacetylase, HAT histone acetyl transferase, SUV39H1 histone-lysine N-methyltransferase, HP1 heterochromatin protein 1, nuc nucleosome, PIC preinitiation complex, RNA POLII RNA polymerase II)