Variants in the CYP7B1 gene region do not affect natural resistance to HIV-1 infection

Retrovirology

Table 2 Association of rs6966198 and rs10808739 with HIV-1 infection susceptibility

Sample	Genotype frequency				Allelic frequency		p ^b_additive	p ^c_dominant	p ^d_recessive
Sample	CC	CT	TT	CT + TT^a	C	T	p ^b_additive	p ^c_dominant	p ^d_recessive
rs6966198
Italian HESN	0.648	0.304	0.048	0.35	0.8	0.2	0.112	0.137	0.373
Italian SP	0.551	0.373	0.076	0.45	0.737	0.263	0.112	0.137	0.373
Colombian HESN	0.661	0.274	0.065	0.339	0.798	0.202	0.557	0.83	0.309
Colombian SP	0.681	0.298	0.021	0.319	0.83	0.17	0.557	0.83	0.309
Peruvian HESN	0.685	0.292	0.023	0.315	0.831	0.169	0.147	0.048	0.399
Peruvian SP	0.805	0.152	0.043	0.196	0.88	0.12	0.147	0.048	0.399

Sample	Genotype frequency				Allelic frequency		p ^b_additive	p ^c_dominant	p ^d_recessive
Sample	GG	GA	AA	–	G	A	p ^b_additive	p ^c_dominant	p ^d_recessive
rs10808739
Italian HESN	0.58	0.33	0.09	–	0.746	0.254	0.392	0.267	0.961
Italian SP	0.5	0.412	0.088	–	0.706	0.294	0.392	0.267	0.961
Colombian HESN	0.71	0.226	0.064	–	0.823	0.177	0.831	0.787	0.275
Colombian SP	0.686	0.294	0.02	–	0.833	0.167	0.831	0.787	0.275
Peruvian HESN	0.794	0.198	0.008	–	0.893	0.107	0.302	0.38	0.389
Peruvian SP	0.741	0.235	0.024	–	0.859	0.141	0.302	0.38	0.389

ISSN: 1742-4690