The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells

Kumar, Nitasha A.; Cheong, Karey; Powell, David R.; da Fonseca Pereira, Candida; Anderson, Jenny; Evans, Vanessa A.; Lewin, Sharon R.; Cameron, Paul U.

doi:10.1186/s12977-015-0204-2

Retrovirology

Table 1 Effects on HIV infection of genes differentially expressed by latency inducing and non-inducing antigen presenting cell subpopulations using RNA-seq

From: The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4⁺ T-cells

Gene name	Gene symbol	Function
Gene name	Gene symbol	Antigen presentation	Apoptosis regulation	Cell proximity presentation	Immune checkpoint blocker	T-cell activation	Unknown
Number of genes expressed in each category		1	5	32	5	9	1
CD1d molecule	CD1d	–^,*
Lectin, galactoside-binding, soluble, 1	LGALS1		+
Vasoactive intestinal peptide receptor 1	VIPR1		+^*
EF-hand domain family, member D2	EFHD2		–
Tumor necrosis factor receptor superfamily, member 10a	TNFRSF10A		+
Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	TNFRSF10D		+
Acid phosphatase, prostate	ACPP			+
ADAM metallopeptidase domain 15	ADAM15			+
Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	CD18			+^,*
Carcinoembryonic antigen-related cell adhesion molecule 4	CEACAM4			+
C-type lectin domain family 4, member G	CLEC4G			–^,*
C-type lectin domain family 7, member A	CLEC7A			+^*
Cytotoxic and regulatory T cell molecule	CRTAM			–^**
Colony stimulating factor 3 receptor (granulocyte)	CSF3R			+^*
Ephrin-B1	EFNB1			–
Endoglin	END			+^*
Endothelial cell adhesion molecule	ESAM			+
G protein-coupled receptor 133	GPR133			+
Intercellular adhesion molecule 3	ICAM3			+^*
Leucine rich repeat containing 8 family, member C	LRRC8C			+
Multiple EGF-like-domains 9	MEGF9			+
Membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	MPP7			+
Macrophage scavenger receptor 1	MSR1			+
Osteoclast associated, immunoglobulin-like receptor	OSCAR			+
Plexin domain containing 2	PLXDC2			+
Syndecan 3	SDC3			+^*
CD33 molecule	CD33			–	–
Sphingosine-1-phosphate lyase 1	SGPL1			+	+
Sialic acid binding Ig-like lectin 10	SIGLEC10			–^*	–
Sialic acid binding Ig-like lectin 7	SIGLEC7			+^**	+
Sialic acid binding Ig-like lectin 9	SIGLEC9			–	–
Synaptojanin 2 binding protein	SYNJ2BP			+	+
T-cell lymphoma invasion and metastasis 1	TIAM1			+^*	+
Transmembrane protein 2	TMEM2			+	+
Tetraspanin 17	TSPAN17			–	–
C-type lectin domain family 1, member A	CLEC1A			+		+
Sialic acid binding Ig-like lectin 14	SIGLEC14			+		+
CD101 molecule	CD101				–
CD52 molecule	CD52		–		–
Hepatitis A virus cellular receptor 2	HAVR2/Tim-3				–^**
Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	LILRA6				–
Poliovirus receptor	PVR				+^*
Neuropilin (NRP) and tolloid (TLL)-like 2	NETO2				+
CD48 molecule	CD48					0^**
Interleukin 15 receptor, alpha	IL15RA					–^**
Leucine rich repeat containing 25	LRRC25					+
NFAT activating protein with ITAM motif 1	NFAM1					+
Secreted and transmembrane 1	SECTM1					+
V-set and immunoglobulin domain containing 2	VSIG2					+
CD300e molecule	CD300e					+
CD83 molecule	CD83					0^**
CD86 molecule	CD86					0^**
Ecotropic viral integration site 2A	EVI2A						+

The functional category shown were determined by the description from the DAVID (http://david.abcc.ncifcrf.gov/) and GeneCards (http://genecards.org/) databases
+, increased latent infection; –, inhibition of virus expression, 0, undefined. Genes that were common to the RNA-seq and microarray generated gene lists are in italics. * represent a role in HIV infection of either DC (*) or T-cell (**). Data in Table 1 is presented with additional detail and references in Additional file 3: Supplementary references

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ISSN: 1742-4690

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