Fig. 5

Comparison of gene expression between latency inducing and non-inducing antigen presenting cell subpopulations using RNA-seq. a Gene expression profiles common to the latency inducing APC subpopulations (CD1c⁺ mDC, SLAN⁺ mDC and CD14⁺ monocytes) compared with non-latency inducing APC (pDC) were selected (fold change ≥2, p < 0.01). Using GeneCodis, these 754 genes were categorised according to cellular compartment expression. b Encoded proteins expressed on APC surface and membrane compartments were further analysed for ability to signal to T-cells and involvement in HIV-1 infection. Representative heat map with >twofold differential gene expression of genes able to signal to T-cells, which are differentially expressed between latency inducing (CD1c⁺ mDC, SLAN⁺ mDC and CD14⁺ monocytes) and non-inducing APC subpopulations (pDC)