Systemic T cell activation is compared to PB CD4+ T cell loss in individual mice. Plots for individual mice of CD4+ T cells (left y axis) and of HLA-DR+CD38+CD8+ T cells (right y axis) over the infection time course are shown. Top
row all six JRCSF infected mice show increases in CD8+ T cell activation concomitant to PB CD4+ T cell loss. Middle
row JRCSFNefdd infected BLT mice show very low T cell activation and no CD4+ T cell loss except for JRCSFNefdd 6 which had a drop in CD4+ at week 17. Bottom
row uninfected mice show very low T cell activation and no CD4+ T cell loss.