Figure 5

Systemic T cell activation is compared to PB CD4⁺ T cell loss in individual mice. Plots for individual mice of CD4⁺ T cells (left y axis) and of HLA-DR⁺CD38⁺CD8⁺ T cells (right y axis) over the infection time course are shown. Top row all six JRCSF infected mice show increases in CD8⁺ T cell activation concomitant to PB CD4⁺ T cell loss. Middle row JRCSFNefdd infected BLT mice show very low T cell activation and no CD4⁺ T cell loss except for JRCSFNefdd 6 which had a drop in CD4⁺ at week 17. Bottom row uninfected mice show very low T cell activation and no CD4⁺ T cell loss.