Systemic T cell activation during infection with JRCSF and JRCSFNefdd. Systemic T cell activation was assessed by the levels of HLA-DR+CD38+CD8+ relative to total CD8+ T cells in blood. a Representative dot plots for the presence of activated CD8+ T cells in blood of uninfected, JRCSF-infected (JRCSF 1) and JRCSFNefdd-infected (JRCSFNefdd 6) mice. Gating protocol was performed as indicated in “Methods”. Data shown are from 12 wpi. b Aggregate data of CD8+ T cell activation over the course of 17 weeks of infection is shown for uninfected (n = 4), JRCSF infected (n = 6) and JRCSFNefdd infected (n = 5) mice.