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Figure 10 | Retrovirology

Figure 10

From: Human T-cell leukemia virus type-I Tax induces the expression of CD83 on T cells

Figure 10

Enhancement of Tax1 expression and HTLV-I infectivity by prostaglandin E2 (PGE2). a ATL-patient-derived IL-2-dependent CD4+ T cell lines (ATL-056i and ATL-003i) were cultured in the presence or absence of 100 ng/ml PGE2 for 24 h and examined for the expression of Tax1 and HTLV-I envelope gp46 antigen by FCM. The levels of HTLV-I gag p24 released into the culture supernatants were determined by ELISA and are shown on the top of the dot plot. b ATL-056i cells suspended at 1 × 106 cells/ml either untreated or treated with PGE2 for 24 h were co-cultured with an equal volume of Jurkat cells (1 × 106 cells/ml) for an additional 18 h in triplicate wells. Then, the numbers of syncytia (per ml) were counted manually as described previously [26].

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