Figure 4

HIV-1 and HIV-2 mutation frequencies and spectra are similar in the absence of G-to-A hypermutation. a Analysis of mutation frequency in the absence of G-to-A hypermutation. HIV-1 and HIV-2 mutation frequencies were determined either including or excluding G-to-A hypermutants, with the results superimposed. The relative percentage of the total data that can be attributed (or not attributed) to G-to-A hypermutation is indicated within the bars. b Analysis of HIV-1 and HIV-2 mutation spectra in the absence of G-to-A hypermutation. HIV-1 and HIV-2 mutation spectra were examined after excluding all G-to-A hypermutants. Mutation spectra were determined by dividing the frequency of each type of mutation by the total mutation frequency, with the results expressed as a percentage. Data in both panels represent the mean of three experimental replicates.