Figure 8

Molecular models of CCR5 binding the V3 tip of MVC-Sens Env (left) or the V3 tip of MVC-Res Env and MVC (right). a and b Three-dimensional view of the complexes. The backbone of CCR5 is represented as grey ribbons and the backbone of V3 as green ribbons. The side chains of amino acids involved in inter-molecular interactions are represented as sticks. MVC is represented as sticks. c and d Schematic view of binding modes. Light, medium and dark grey boxes represent the receptor residues in ECL2, N-terminus, and TM7, respectively. H-bonds are indicated with dotted black lines, aromatic stacking with a dotted blue line and ionic bonds with dotted red lines. The thicker the line, the more stable is the interaction.