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Figure 2 | Retrovirology

Figure 2

From: A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity

Figure 2

Susceptibility of MVC-Sens and MVC-Res to inhibition by MVC and TAK 779. U87-CD4/CCR5 cells (a, b) or PBMCs (c, d) were inoculated with equal amounts of MVC-Sens or MVC-Res (10 ng of Gag p24) in the absence or in the presence of increasing concentrations of MVC (a, c) or TAK 779 (b, d). Data points are expressed as percent inhibition of infection relative to control infection measured in the absence of MVC (0%) and were fitted to a sigmoidal dose–response model with a variable slope. Representative experiments out of five independent experiments performed in triplicate are shown.

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Retrovirology

ISSN: 1742-4690

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