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Figure 1 | Retrovirology

Figure 1

From: Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes

Figure 1

Macrophage infectivity for Envs selected for cervical explant studies. a Infectivity for macrophages (FFU/mL) for Env+ pseudoviruses (left panel). Mac-tropic Envs mediated significantly higher levels of macrophage infectivity compared to T/F/acute and late stage non-mac-tropic Envs (p values = <0.0001) right panel. b Macrophage infection plotted as a percent of TZM-bl infectivity (left panel). Correction of Env+ pseudovirus infectivity for different levels of infectivity on TZM-bl cells confirms that mac-tropic Envs mediated significantly higher levels of macrophage infectivity compared to T/F/acute and late stage non-mac-tropic Envs (p values = <0.0001) right panel. Left panel in a and b show means and standard errors from infectivities measured on macrophages derived from at least three donors, right panels show geometric means with 95% confidence intervals. p values were calculated using unpaired, two-tailed t tests in Prism 6.0f.

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Retrovirology

ISSN: 1742-4690

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