Fig. 7
From: Functional bottlenecks for generation of HIV-1 intersubtype Env recombinants
Model of the C1/C5/ecto-gp41 core in the crystal structure of the HIV-1 gp140 trimer. This figure is derived from the recent 4.7 Å crystal structure of a soluble, cleaved BG505 SOSIP.664 gp140 trimer in complex with a potent bnAb, PGT122 [37] (PDB - 4NCO). The interaction between the gp120 C1, C5, and ecto-gp41 domains is highlighted. For this model, the bnAb PGT122 is hidden, viral membrane would be on top, and CD4/CCR5 would engage at the bottom of each view. The Env trimer “core” of the C1, C5, and ecto-gp41 of each gp140 subunit is shown in panel (a), turned 90O in (b), and stripped of all other gp120 residues in panel (c). Finally, each gp140 subunit of the trimer is shown in panel (d)