Figure 4
Pathologic changes in the spleen and lymph nodes of the transgenic mice. Tissue sections from the intestines, spleens, lymph nodes, kidneys, lungs and livers of ELR1/eCT1 and wild-type mice were prepared after intraperitoneal injections with EIAVDLV34 for four weeks. The pathologic changes of organs stained with hematoxylin-eosin were analyzed by optical microscopy. Large areas of focal hemosiderin deposits were observed in the spleen (arrows), but not in the other organs of ELR1/eCT1 mice. In addition, no such areas were observed in wild-type mice. The medullary lymphocytes decreased significantly in the lymph nodes (arrows), but not in the other organs of ELR1/eCT1 mice. No such decrease was observed in wild-type mice.