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Figure 4 | Retrovirology

Figure 4

From: Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions

Figure 4

Close-up views of regulatory regions in the olfactory and CT49 loci. The subfigures show close-up views of regulatory positions P1, P2 and so on, from Figure 3. (A) In K562, the promoter position P1 corresponds to an ERV9-LTR12 repeat in the olfactory (OR) locus. (B) In K562, an ERV9-LTR is bidirectionally active giving rise to spliced transcript of opposite directions in the CT49 locus. (C-D) In H1 hESC the promoter positions (P2-P3) are positioned in repeat-dense regions in CT49 that contain multiple LTRs and non-LTR repeats, as well as multiple potential TSSs (directions indicated by + and –). The promoter regions are drawn to scale and correspond to those shown in Figure 3 from ENCODE/Broad. Please refer to the legend of Figure 2 details of data presentation.

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Retrovirology

ISSN: 1742-4690

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