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Table 3 List of GO biological processes relevant for antigen-presenting cell function found significantly enriched after Bonferroni correction in the 5991 protein coding genes commonly expressed by sorted tonsil-derived Siglec-1 positive cells and the different types of myeloid cells exposed to IFNα

From: HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

GO biological process Genes in GO process Genes found Expected P-value
Immune system process (GO:0002376) 1875 791 5,10E + 05 1,38E-27
Regulation of immune system process (GO:0002682) 1090 439 2,96E + 05 3,63E-09
Positive regulation of immune system process (GO:0002684) 636 273 1,73E + 05 2,06E-06
Defense response (GO:0006952) 1256 490 3,42E + 05 1,30E-08
Regulation of defense response (GO:0031347) 502 218 1,37E + 05 1,69E-04
Immune response (GO:0006955) 1153 476 3,14E + 05 3,06E-12
Regulation of immune response (GO:0050776) 712 303 1,94E + 05 2,89E-07
Positive regulation of immune response (GO:0050778) 428 200 1,16E + 05 2,52E-06
Activation of immune response (GO:0002253) 344 175 9,35E + 04 7,68E-08
Immune response-activating signal transduction (GO:0002757) 296 165 8,05E + 04 2,15E-10
Immune response-regulating signaling pathway (GO:0002764) 403 202 1,10E + 05 3,18E-09
Immune effector process (GO:0002252) 399 194 1,09E + 05 1,82E-07
Response to virus (GO:0009615) 250 129 6,80E + 04 7,85E-05
Innate immune response (GO:0045087) 773 362 2,10E + 05 6,72E-16
Regulation of innate immune response (GO:0045088) 246 141 6,69E + 04 4,76E-09
Positive regulation of innate immune response (GO:0045089) 178 106 4,84E + 04 1,63E-06
Activation of innate immune response (GO:0002218) 148 94 4,02E + 04 1,04E-06
Innate immune response-activating signal transduction (GO:0002758) 141 91 3,83E + 04 1,05E-06
Antigen processing and presentation (GO:0019882) 222 142 6,04E + 04 5,93E-13
Of peptide antigen (GO:0048002) 186 126 5,06E + 04 8,41E-13
Of peptide antigen via MHC class I (GO:0002474) 101 81 2,75E + 04 3,02E-10
Of exogenous antigen (GO:0019884) 172 119 4,68E + 04 1,77E-12
Of exogenous peptide antigen (GO:0002478) 170 117 4,62E + 04 5,08E-12
Of exogenous peptide antigen via MHC class I (GO:0042590) 79 64 2,15E + 04 3,07E-07
Of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479) 75 61 2,04E + 04 9,76E-07
Pattern recognition receptor signaling pathway (GO:0002221) 138 89 3,75E + 04 1,97E-06
Toll-like receptor signaling pathway (GO:0002224) 120 80 3,26E + 04 5,80E-06
Toll-like receptor 3 signaling pathway (GO:0034138) 79 57 2,15E + 04 5,06E-04
Toll-like receptor 4 signaling pathway (GO:0034142) 95 63 2,58E + 04 1,52E-03
Toll-like receptor 9 signaling pathway (GO:0034162) 73 52 1,99E + 04 4,80E-03
TRIF-dependent toll-like receptor signaling pathway (GO:0035666) 76 54 2,07E + 04 2,56E-03
Cellular response to cytokine stimulus (GO:0071345) 457 218 1,24E + 05 3,25E-08
Cytokine-mediated signaling pathway (GO:0019221) 339 169 9,22E + 04 1,08E-06
Regulation of type I interferon production (GO:0032479) 106 78 2,88E + 04 9,02E-08
Positive regulation of type I interferon production (GO:0032481) 75 56 2,04E + 04 2,13E-04
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Retrovirology

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