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Table 3 List of GO biological processes relevant for antigen-presenting cell function found significantly enriched after Bonferroni correction in the 5991 protein coding genes commonly expressed by sorted tonsil-derived Siglec-1 positive cells and the different types of myeloid cells exposed to IFNα

From: HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

GO biological process

Genes in GO process

Genes found

Expected

P-value

Immune system process (GO:0002376)

1875

791

5,10E + 05

1,38E-27

Regulation of immune system process (GO:0002682)

1090

439

2,96E + 05

3,63E-09

Positive regulation of immune system process (GO:0002684)

636

273

1,73E + 05

2,06E-06

Defense response (GO:0006952)

1256

490

3,42E + 05

1,30E-08

Regulation of defense response (GO:0031347)

502

218

1,37E + 05

1,69E-04

Immune response (GO:0006955)

1153

476

3,14E + 05

3,06E-12

Regulation of immune response (GO:0050776)

712

303

1,94E + 05

2,89E-07

Positive regulation of immune response (GO:0050778)

428

200

1,16E + 05

2,52E-06

Activation of immune response (GO:0002253)

344

175

9,35E + 04

7,68E-08

Immune response-activating signal transduction (GO:0002757)

296

165

8,05E + 04

2,15E-10

Immune response-regulating signaling pathway (GO:0002764)

403

202

1,10E + 05

3,18E-09

Immune effector process (GO:0002252)

399

194

1,09E + 05

1,82E-07

Response to virus (GO:0009615)

250

129

6,80E + 04

7,85E-05

Innate immune response (GO:0045087)

773

362

2,10E + 05

6,72E-16

Regulation of innate immune response (GO:0045088)

246

141

6,69E + 04

4,76E-09

Positive regulation of innate immune response (GO:0045089)

178

106

4,84E + 04

1,63E-06

Activation of innate immune response (GO:0002218)

148

94

4,02E + 04

1,04E-06

Innate immune response-activating signal transduction (GO:0002758)

141

91

3,83E + 04

1,05E-06

Antigen processing and presentation (GO:0019882)

222

142

6,04E + 04

5,93E-13

Of peptide antigen (GO:0048002)

186

126

5,06E + 04

8,41E-13

Of peptide antigen via MHC class I (GO:0002474)

101

81

2,75E + 04

3,02E-10

Of exogenous antigen (GO:0019884)

172

119

4,68E + 04

1,77E-12

Of exogenous peptide antigen (GO:0002478)

170

117

4,62E + 04

5,08E-12

Of exogenous peptide antigen via MHC class I (GO:0042590)

79

64

2,15E + 04

3,07E-07

Of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)

75

61

2,04E + 04

9,76E-07

Pattern recognition receptor signaling pathway (GO:0002221)

138

89

3,75E + 04

1,97E-06

Toll-like receptor signaling pathway (GO:0002224)

120

80

3,26E + 04

5,80E-06

Toll-like receptor 3 signaling pathway (GO:0034138)

79

57

2,15E + 04

5,06E-04

Toll-like receptor 4 signaling pathway (GO:0034142)

95

63

2,58E + 04

1,52E-03

Toll-like receptor 9 signaling pathway (GO:0034162)

73

52

1,99E + 04

4,80E-03

TRIF-dependent toll-like receptor signaling pathway (GO:0035666)

76

54

2,07E + 04

2,56E-03

Cellular response to cytokine stimulus (GO:0071345)

457

218

1,24E + 05

3,25E-08

Cytokine-mediated signaling pathway (GO:0019221)

339

169

9,22E + 04

1,08E-06

Regulation of type I interferon production (GO:0032479)

106

78

2,88E + 04

9,02E-08

Positive regulation of type I interferon production (GO:0032481)

75

56

2,04E + 04

2,13E-04