Figure 3

JSRV-infected lung slice and early experimental OPA show a similar pattern of JSRV-SU labeling. Sections of JSRV-infected tissue were labeled with a monoclonal antibody to JSRV Env (SU) by IHC. Positive labeling is shown by brown pigment. A, B) JSRV-infected lung slice 8 dpi; C, D) JSRV-infected lung slice 16 dpi; E, F) Lung tissue from lambs experimentally infected with JSRV 10 dpi; G, H) Lung slices infected with control virus JSRV-∆RT 16 dpi showed no labeling. I, J) Lung slices infected with pooled supernatant of previous JSRV-infected lung slices 12 dpi. K, L) Lung slices infected with pooled supernatant of previous JSRV-∆RT infected lung slices 12 dpi. Dashed circles in A, C, E, G, I and K indicate the regions shown at higher magnification in B, D, F, H, J and L, respectively.