Figure 8
From: Balanced splicing at the Tat-specific HIV-1 3′ss A3 is critical for HIV-1 replication
Model for SRSF2 and SRSF6-mediated 3′ss activation. (A) SRSF6 and hnRNP A/B proteins compete for binding to their overlapping binding sites located within ESE2 and ESS2. Depending on the SRSF6 binding efficiency (B), SRSF2 interacts with the upstream ESEtat and guides spliceosomal components to 3′ss A3. (C) Inactivation of ESEtat is associated with a failure in efficient spliceosome recruitment irrespective of higher SRSF6 binding (D).