Figure 7

Naïve, central and effector memory CD4 ⁺ and CD8 ⁺ T cells. Changes from baseline of naïve, Tem and Tcm (A, B) CD4⁺ and (C, D) CD8⁺ T cell percentage at years 1, 2 and 3 for vaccinees (left panels) (n = 94 at year 1 ; n = 75 at year 2 ; n = 32 at year 3) and OBS subjects (right panels) (n = 32 at year 1 ; n = 20 at year 2). Data are presented as mean values with standard error. A longitudinal analysis for repeated measurements was applied. P-values assess the values at year 1, 2 or 3 after immunization versus baseline values.