Table 1 HLA-B*07:02, 42:01, 42:02 and 81:01-associated TL9-p24 and RM9-Nef HIV-1 polymorphisms
Epitope | HLA-B | HXB2 location | Escape variant selected a | Sequence b | % HLA match | % HLA mismatch | P | Q c | N |
|---|---|---|---|---|---|---|---|---|---|
TL9-p24 | 42:01 | 182 | T | EGATP T DLNTMLNTV | 9 | 1 | 7.0E-07 | 2.4E-04 | 1279 |
81:01 | 177 | D | DGATPQDLNTMLNTV | 7 | 1 | 4.4E-05 | 1.1E-02 | 1283 | |
81:01 | 182 | E | EGATP E DLNTMLNTV | 5 | 0 | 2.1E-08 | 7.6E-06 | 1282 | |
81:01 | 182 | G | EGATP G DLNTMLNTV | 8 | 1 | 6.2E-06 | 1.8E-03 | 1281 | |
81:01 | 182 | S | EGATP S DLNTMLNTV | 21 | 3 | 6.2E-12 | 4.3E-09 | 1277 | |
81:01 | 186 | S | EGATPQDLN S MLNTV | 31 | 3 | 1.8E-24 | 8.5E-21 | 1285 | |
81:01 | 191 | I | EGATPQDLNSMLNTI | 9 | 2 | 3.2E-06 | 9.6E-04 | 1288 | |
RM9-Nef | 07:02 | 71 | K | FPVK PQVPLRPMTYK | 41 | 6 | 7.4E-05 | 2.4E-02 | 1293 |
42:02 | 81 | F | FPVRPQVPLRPMTFK | 34 | 9 | 1.4E-04 | 4.0E-02 | 1126 | |
81:01 | 76 | V | FPVRPQVP V RPMTYK | 34 | 6 | 3.3E-16 | 4.8E-13 | 1327 | |
81:01 | 76 | T | FPVRPQVP T RPMTYK | 17 | 1 | 1.9E-15 | 2.3E-12 | 1327 | |
81:01 | 76 | I | FPVRPQVP I RPMTYK | 7 | 0 | 4.0E-06 | 2.1E-03 | 1327 |