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Table 1 HLA-B*07:02, 42:01, 42:02 and 81:01-associated TL9-p24 and RM9-Nef HIV-1 polymorphisms

From: A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

Epitope HLA-B HXB2 location Escape variant selected a Sequence b % HLA match % HLA mismatch P Q c N
TL9-p24 42:01 182 T EGATP T DLNTMLNTV 9 1 7.0E-07 2.4E-04 1279
81:01 177 D DGATPQDLNTMLNTV 7 1 4.4E-05 1.1E-02 1283
81:01 182 E EGATP E DLNTMLNTV 5 0 2.1E-08 7.6E-06 1282
81:01 182 G EGATP G DLNTMLNTV 8 1 6.2E-06 1.8E-03 1281
81:01 182 S EGATP S DLNTMLNTV 21 3 6.2E-12 4.3E-09 1277
81:01 186 S EGATPQDLN S MLNTV 31 3 1.8E-24 8.5E-21 1285
81:01 191 I EGATPQDLNSMLNTI 9 2 3.2E-06 9.6E-04 1288
RM9-Nef 07:02 71 K FPVK PQVPLRPMTYK 41 6 7.4E-05 2.4E-02 1293
42:02 81 F FPVRPQVPLRPMTFK 34 9 1.4E-04 4.0E-02 1126
81:01 76 V FPVRPQVP V RPMTYK 34 6 3.3E-16 4.8E-13 1327
81:01 76 T FPVRPQVP T RPMTYK 17 1 1.9E-15 2.3E-12 1327
81:01 76 I FPVRPQVP I RPMTYK 7 0 4.0E-06 2.1E-03 1327
  1. aEscape polymorphism shows the amino acid selected in that particular HXB2 location, also indicated by bold face.
  2. bEpitope is italics with the consensus shown for +/- 3 amino acids; bold indicates the site of polymorphism.
  3. cOnly Q-values <0.05 are included.