An integrated map of HIV-1 genomic diversity and protein structures. All 15 HIV-1 proteins are mapped in the circle with 8 layers, showing the schematic view of HIV-1 peptide inhibitors (layer 1), protein secondary structures (layer 2, dark blue: helix structures, light blue: beta-strand structures, white: random-coil structures), protein disorder scores (layer 3), amino acid diversity at individual positions (layer 4), human CD4/CD8/antibody epitope regions (layer 5, three sub-layers from inside to outside represent CD8+ T cell, CD4+ T cell and antibody epitope regions), HXB2 reference indices (layer 6), peptide-inhibitor-derived regions (layer 7) and the protein structures are colored according to the diversity of amino acid positions (layer 8, low: 0%, high: ≥30%). Three major genes (gag, pol, env) are annotated in the center. Structures of multimeric HIV-1 proteins are shown outside the circle and different protein units are colored separately. The list of PDB data is available in Additional file 2: Table S5. Visualization software: Circos V0.64 (http://circos.ca/).