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Table 3 Kinetic parameters for AZTMP removal by ATP in SFVmac PR-RTs

From: AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase

Enzyme

K M (μM)

p-value

V max (nM/min)

p-value

S345T

811 (±127)

0.004

110.7 (±6.7)

0.02

mt2a

893 (±268)

0.011

112.4 (±14.7)

0.08

mt2c

899 (±73)

0.001

108.7 (±11.2)

0.06

mt3

142 (±44)

0.226

100.5 (±22.5)

0.14

mt4

241 (±101)

-

131.2 (±5.6)

-

  1. The p-values were calculated with the unpaired t-test, each variant was compared with the highly resistant mt4 variant. p-values ≤ 0.05 were considered significant.
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Retrovirology

ISSN: 1742-4690

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