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Table 3 Kinetic parameters for AZTMP removal by ATP in SFVmac PR-RTs

From: AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase

Enzyme K M (μM) p-value V max (nM/min) p-value
S345T 811 (±127) 0.004 110.7 (±6.7) 0.02
mt2a 893 (±268) 0.011 112.4 (±14.7) 0.08
mt2c 899 (±73) 0.001 108.7 (±11.2) 0.06
mt3 142 (±44) 0.226 100.5 (±22.5) 0.14
mt4 241 (±101) - 131.2 (±5.6) -
  1. The p-values were calculated with the unpaired t-test, each variant was compared with the highly resistant mt4 variant. p-values ≤ 0.05 were considered significant.