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Figure 2 | Retrovirology

Figure 2

From: Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

Figure 2

PD-1 blockade enhances both T and B cell responses during chronic HIV/SIV infection. PD-1 blockade mediated functional restoration of exhausted virus-specific CD8+ T cells gain their qualities to clear viral antigens and control chronic viral infection. Blockade of PD-1 in virus specific CD4+ T cells restore functions associated with CD8+ T cell help and B-cell activation. Impaired B cells restore functions and produce virus-specific antibody following in vivo PD-1 blockade.

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