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Figure 4 | Retrovirology

Figure 4

From: Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

Figure 4

Baseline iNKT LAG-3 and PD-1 expression among healthy HIV-N (n = 14), HIV+ (n = 9) and HIV+ ART (n = 15) women. Comparison of (A) iNKT LAG-3 expression and (B) iNKT PD-1 expression among HIV-N, HIV+ and HIV+ ART groups in a follow-up study. (C) Correlation between LAG-3 and PD-1 expression all participants and HIV+/HIV+ ART women. (D) Comparison of PD-1 expression on iNKTs compared to conventional CD8+ T cells among both healthy and HIV-infected women. (E) PD-1 expression on CD8+ T cells among HIV+ ART naïve women (n = 9) compared to healthy controls (n = 16). (F) Correlation between LAG-3 and PD-1 on CD8+ T cells. Statistical comparisons made by Kruskal-Wallis (with Dunn’s post-test), Wilcoxon test, Mann–Whitney and Spearman correlation *p < 0.05, **p < 0.01, ****p < 0.0001.

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