Patient
|
Clade
|
Non-mac-tropic
|
Mac-tropic
|
Reference
|
---|
|
Env
|
Origin
|
Full ID
|
Env
|
Origin
|
Full ID
|
---|
AIDS patients
| | | | | | | | |
NA20
|
B
|
LN8
|
LN1
| |
B59
|
FL2
| |
[3]
|
| | | | |
B501
|
FL
| | |
NA420
|
B
|
LN40
|
LN
| |
B33
|
FL
| |
[3]
|
JR
|
B
|
JR-CSF
|
CSF3
| |
JR-FL
|
FL
| |
[4]
|
P1114
|
B
|
98-27
|
Plasma
| |
98-15
|
Plasma
| |
[3]
|
P7766
|
B
|
SP1
|
Spleen
|
SP13-33-41
|
FL2
|
FL
|
FL19-56-66
|
[23]
|
P10017
|
B
|
SP2
|
Spleen
|
SP10-9-65
|
FL1
|
FL
|
FL9-1-2
|
[23]
|
P6568
|
B
|
SP1
|
Spleen
|
SP6-11-9
|
FL1
|
FL
|
FL11-1-249
|
[23]
|
CA110
|
B
|
SP2
|
Spleen
|
SP53-23-131
|
OC1
|
OL4
|
OC58-11-57
|
[23]
|
| |
SP3 SP4
|
Spleen Spleen
|
SP53-6-122 SP52-16-50
|
SP1
|
Spleen
|
SP52-13-34
| |
T/F
| | | | | | | | |
3 T
|
B
|
3 T
|
Plasma
|
p1054.TC4.1499
| | | |
[60]
|
6 T
|
B
|
6 T
|
Plasma
|
p63358.p3.4013
| | | |
[60]
|
15 T
|
B
|
15 T
|
Plasma
|
p700010040.C9.4520
| | | |
[60]
|
19 T
|
B
|
19 T
|
Plasma
|
pPRB958_06.TB1.4305
| | | |
[60]
|
Acute Stage
| | | | | | | | |
R463F
|
A1
|
R463F
|
Plasma
|
R463FPL16MAR07EnvE44
| | | |
[62]
|
R880F
|
A1
|
R880F
|
Plasma
|
R880FPL12JAN07EnvA6
| | | |
[63]
|
Z185F
|
C
|
Z185F
|
Blood
|
Z185FPB24AUG02ENV3.1
| | | |
[63,64]
|
Z205F
|
C
|
Z205F
|
Blood
|
Z205FPB27MAR03ENV1.1
| | | |
[63,64]
|
R66M
|
A/C
|
R66M
|
Plasma
|
R66MPL7MAR06.3A9Env
| | | |
[63]
|
Z1792M
|
C
|
Z1792M
|
Plasma
|
Z1792MPL18DEC07.3G7Env2
| | | |
[63]
|
Z201M
|
C
|
Z201M
|
Plasma
|
Z201MPL7FEB03ENV2.1
| | | |
[13]
|
Z221M
|
C
|
Z221M
|
Plasma
|
Z221MPL7MAR03ENV2.1
| | | |
[13]
|
Z153M
|
C
|
Z153M
|
Plasma
|
Z153MPL13MAR02ENV5.1
| | | |
[13]
|
- We selected pairs of highly mac-tropic and non-mac-tropic R5 Envs from 8 subtype B infected AIDS patients (including JR-FL and JR-CSF) for study. For subject NA20, we included 2 highly mac-tropic Envs. For CA110, we included two highly mac-tropic Envs and two non-mac-tropic spleen Envs. Except for JR-FL and JR-CSF, all Envs had been PCR amplified directly from patient tissues. We also included 13 diverse R5 Envs previously reported as T/F or isolated from the acute stage of infection. In this group, we included Envs from different subtypes. 1. Lymph node; 2. Frontal lobe; 3. Cerebral spinal fluid; 4. Occipital lobe.