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Figure 2 | Retrovirology

Figure 2

From: HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages

Figure 2

Infection of Jurkat/CCR5, primary CD4+ T-cells and primary MDDCs by pseudovirions carrying mac-tropic and non-mac-tropic R5 envelopes. Env+ GFP-reporter pseudovirus infection of Jurkat/CCR5 (A), primary CD4+ T-cells (B) and LPS matured MDDCs (C). Left panels shows FFU measured as GFP+ cells per ml of input virus. Right panels show infectivity as a percent of TZM-bl infectivity. Significant differences were evaluated using Mann Whitney or Wilcoxon matched pair tests as described in Methods. Only the p values that were significant are shown. Symbol colour designations are the same as described in Figure 1. Please also refer to Additional file 1: Figure S3, where FFU/ml for each Env+ pseudovirus is presented in bar graphs with standard deviation bars shown, while the column scatter plot of infectivity as a percent of TZM-bl infectivity is presented with each point labeled for Env used. Median values are marked.

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