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Figure 1 | Retrovirology

Figure 1

From: HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages

Figure 1

Env+ pseudovirion infection of HeLa TZM-bl and macrophages. (A) Macrophage-tropic R5 Envs mediate 100-1000-fold higher infection of macrophages compared to T/F/acute and late disease non-mac-tropic R5 Envs. (B) Several late disease non-mac-tropic Envs and most T/F/acute Envs mediated lower infection of HeLa TZM-bl cells compared to macrophage tropic Envs. (C) Plotting macrophage infectivity titers as a percent of TZM-bl titers suggests that T/F/acute Envs are not as non-mac-tropic as late disease non-mac-tropic Envs. Significant differences were evaluated using Mann Whitney or Wilcoxon matched pair tests as described in Materials and Methods. Pseudoviruses carrying clade B Envs are represented by black symbols, those with clade C Envs by light gray symbols, clade A by hatched symbols and CRF A/C by dark gray. Median values are marked.

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