Sequence alignment of A3H HapII (residues 1 to 183) and four A3 deaminase-active proteins whose structures have been solved: A3A (1 to 199) [
], A3C (1 to 190) [
], A3F-CTD (185–373) [
], and A3G-CTD (191–384) [
] (also see refs. [
]). The A3H residues mutated in this study are highlighted with green asterisks and the active site residues are highlighted in blue. The region inside the square brackets represents the Z domain sequences for all of the proteins. The amino acids that comprise A3H loop 7 are also shown. The sequence alignment was generated using Lasergene software (DNASTAR, Inc., Madison, WI, USA).