Skip to main content

Table 3 Thermodynamic parameters of griffithsin binding to HIV-1 gp120

From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

  Affinity ( μM) ΔH (kcal/mol) ΔG TΔS ΔH/TΔS
GRFT 0.008 ± 0.004 – 30.4 + 0.3 – 11.2 ± 0.3 – 19.2 ± 0.3 1.58
mGRFT 0.112 ± 0.050 – 35.5 + 0.6 – 9.5 ± 0.7 – 26.0 ± 0.7 1.36
2mGRFT 0.005 ± 0.002 – 69.6 + 0.5 – 11.6 ± 0.6 – 59.9 ± 0.5 1.16
2mGRFT3 0.003 ± 0.001 – 47.2 + 0.6 – 11.8 ± 0.2 – 35.4 ± 0.6 1.33
3mGRFT 0.003 ± 0.001 – 74.4 + 0.4 – 11.8 ± 0.2 – 62.7 ± 0.4 1.19