Table 3 Thermodynamic parameters of griffithsin binding to HIV-1 gp120
From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus
Affinity ( μM) | ΔH (kcal/mol) | ΔG | TΔS | ΔH/TΔS | |
|---|---|---|---|---|---|
GRFT | 0.008 ± 0.004 | – 30.4 + 0.3 | – 11.2 ± 0.3 | – 19.2 ± 0.3 | 1.58 |
mGRFT | 0.112 ± 0.050 | – 35.5 + 0.6 | – 9.5 ± 0.7 | – 26.0 ± 0.7 | 1.36 |
2mGRFT | 0.005 ± 0.002 | – 69.6 + 0.5 | – 11.6 ± 0.6 | – 59.9 ± 0.5 | 1.16 |
2mGRFT3 | 0.003 ± 0.001 | – 47.2 + 0.6 | – 11.8 ± 0.2 | – 35.4 ± 0.6 | 1.33 |
3mGRFT | 0.003 ± 0.001 | – 74.4 + 0.4 | – 11.8 ± 0.2 | – 62.7 ± 0.4 | 1.19 |