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Table 2 Anti-HIV-1 activity of mGRFT tandemers, mGRFT and native dimeric GRFT in a single cycle Tzm-bl pseudovirus assay system

From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

Envelope

IC50 (nM)

2MG

2MG3

3MG

4MG

GRFT

Subtype B

PVO.4

0.301±0.0818

0.558±0.105

0.270±0.0344

0.185±0.0151

0.0370±0.0173

QH0692.42

0.202±0.0842

0.513±0.0882

0.223±0.0834

0.170±0.0119

0.0473±0.0152

JR-FL

2.09±3.28

5.77±2.16

0.325±0.0702

0.287±0.0476

0.922±0.354

CAAN5342.A2

5.27±3.28

16.9±1.41

0.326±0.0834

0.232±0.0167

7.34±0.927

Median

1.20

3.16

0.298

0.0208

0.485

Subtype C

Du156.12

0.0182±0.00133

0.0616±0.00335

0.0794±0.0252

0.0887±0.0185

0.0324±0.00204

Du179.14

0.158±0.0962

0.144±0.0438

0.124±0.0262

0.0934±0.0291

0.606±0.139

COT6.15

1.46±0.452

2.54±1.01

0.412±0.0588

0.273±0.0396

0.734±0.326

DU151.2

0.694±0.144

1.70±0.0306

0.308±0.0169

0.300±0.0285

1.49±0.225

CAP206.8

0.178±0.0750

0.696±0.0141

0.181±0.0546

0.164±0.0586

2.14±1.26

Median

0.178

0.696

0.181

0.164

0.734

Subtype A

Q23.7

7.26±0.225

7.16±0.512

0.432±0.101

0.276±0.0710

1.19±0.535

Q168.a2

1.55±0.723

5.28±1.48

0.331±0.0398

0.273±0.0167

3.80±1.03

Median

4.41

6.22

0.396

0.274

2.5