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Table 2 Anti-HIV-1 activity of mGRFT tandemers, mGRFT and native dimeric GRFT in a single cycle Tzm-bl pseudovirus assay system

From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

Envelope IC50 (nM)
2MG 2MG3 3MG 4MG GRFT
Subtype B
PVO.4 0.301±0.0818 0.558±0.105 0.270±0.0344 0.185±0.0151 0.0370±0.0173
QH0692.42 0.202±0.0842 0.513±0.0882 0.223±0.0834 0.170±0.0119 0.0473±0.0152
JR-FL 2.09±3.28 5.77±2.16 0.325±0.0702 0.287±0.0476 0.922±0.354
CAAN5342.A2 5.27±3.28 16.9±1.41 0.326±0.0834 0.232±0.0167 7.34±0.927
Median 1.20 3.16 0.298 0.0208 0.485
Subtype C
Du156.12 0.0182±0.00133 0.0616±0.00335 0.0794±0.0252 0.0887±0.0185 0.0324±0.00204
Du179.14 0.158±0.0962 0.144±0.0438 0.124±0.0262 0.0934±0.0291 0.606±0.139
COT6.15 1.46±0.452 2.54±1.01 0.412±0.0588 0.273±0.0396 0.734±0.326
DU151.2 0.694±0.144 1.70±0.0306 0.308±0.0169 0.300±0.0285 1.49±0.225
CAP206.8 0.178±0.0750 0.696±0.0141 0.181±0.0546 0.164±0.0586 2.14±1.26
Median 0.178 0.696 0.181 0.164 0.734
Subtype A
Q23.7 7.26±0.225 7.16±0.512 0.432±0.101 0.276±0.0710 1.19±0.535
Q168.a2 1.55±0.723 5.28±1.48 0.331±0.0398 0.273±0.0167 3.80±1.03
Median 4.41 6.22 0.396 0.274 2.5