From: Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus
Envelope | IC50 (nM) | ||||
---|---|---|---|---|---|
2MG | 2MG3 | 3MG | 4MG | GRFT | |
Subtype B | |||||
PVO.4 | 0.301±0.0818 | 0.558±0.105 | 0.270±0.0344 | 0.185±0.0151 | 0.0370±0.0173 |
QH0692.42 | 0.202±0.0842 | 0.513±0.0882 | 0.223±0.0834 | 0.170±0.0119 | 0.0473±0.0152 |
JR-FL | 2.09±3.28 | 5.77±2.16 | 0.325±0.0702 | 0.287±0.0476 | 0.922±0.354 |
CAAN5342.A2 | 5.27±3.28 | 16.9±1.41 | 0.326±0.0834 | 0.232±0.0167 | 7.34±0.927 |
Median | 1.20 | 3.16 | 0.298 | 0.0208 | 0.485 |
Subtype C | |||||
Du156.12 | 0.0182±0.00133 | 0.0616±0.00335 | 0.0794±0.0252 | 0.0887±0.0185 | 0.0324±0.00204 |
Du179.14 | 0.158±0.0962 | 0.144±0.0438 | 0.124±0.0262 | 0.0934±0.0291 | 0.606±0.139 |
COT6.15 | 1.46±0.452 | 2.54±1.01 | 0.412±0.0588 | 0.273±0.0396 | 0.734±0.326 |
DU151.2 | 0.694±0.144 | 1.70±0.0306 | 0.308±0.0169 | 0.300±0.0285 | 1.49±0.225 |
CAP206.8 | 0.178±0.0750 | 0.696±0.0141 | 0.181±0.0546 | 0.164±0.0586 | 2.14±1.26 |
Median | 0.178 | 0.696 | 0.181 | 0.164 | 0.734 |
Subtype A | |||||
Q23.7 | 7.26±0.225 | 7.16±0.512 | 0.432±0.101 | 0.276±0.0710 | 1.19±0.535 |
Q168.a2 | 1.55±0.723 | 5.28±1.48 | 0.331±0.0398 | 0.273±0.0167 | 3.80±1.03 |
Median | 4.41 | 6.22 | 0.396 | 0.274 | 2.5 |