Illustration of structural elements on gp120 and eOD-GT6. (A) The crystal structure of SOSIP gp140 (accession code 4NCO) is used for the illustration. Gp120 is shown in grey, and regions corresponding to eOD-GT6 are shown in green. Amino acid residues identical between the MCON6 gp120 and eOD-GT6 are shown in yellow. (B and C) VRC01 contact residues are shown in red and V1/V2 and V3 loops are shown as a point of reference. PGT122 (an antibody related to PGT121 and PGT126) that was co-crystallized with SOSIP gp140 is shown with the critical N332 glycosylation site.