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Table 1 Computational prediction of Rev structural models

From: Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding

EIAV Rev sequence

Computational method

Server

Topology of models

Total

Elongated a

Globular b

Unstructured c

Rev165

Ab initio

QUARK

20

0

0

20

Threading

ITASSER

16

14

0

30

LOMETS

6

4

10

20

Homology

PROTINFO

0

6

2

8

Rev135

Ab initio

QUARK

28

0

0

28

Threading

ITASSER

7

17

1

25

LOMETS

3

9

8

20

Homology

PROTINFO

0

1

3

4

Rev∆HVR

Ab initio

QUARK

19

1

0

20

Threading

ITASSER

4

16

0

20

LOMETS

3

8

9

20

RevFDD

Ab initio

QUARK

10

0

0

10

Threading

ITASSER

5

5

0

10

Totals

121

81

33

235

  1. aElongated: models with an unbroken extended alpha helix in the central region.
  2. bGlobular: models with kinks in the central region.
  3. cUnstructured: models with an unfolded topology or missing C-terminal residues encompassing ARM-2.