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Table 1 Computational prediction of Rev structural models

From: Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding

EIAV Rev sequence Computational method Server Topology of models Total
Elongated a Globular b Unstructured c
Rev165 Ab initio QUARK 20 0 0 20
Threading ITASSER 16 14 0 30
LOMETS 6 4 10 20
Homology PROTINFO 0 6 2 8
Rev135 Ab initio QUARK 28 0 0 28
Threading ITASSER 7 17 1 25
LOMETS 3 9 8 20
Homology PROTINFO 0 1 3 4
Rev∆HVR Ab initio QUARK 19 1 0 20
Threading ITASSER 4 16 0 20
LOMETS 3 8 9 20
RevFDD Ab initio QUARK 10 0 0 10
Threading ITASSER 5 5 0 10
Totals 121 81 33 235
  1. aElongated: models with an unbroken extended alpha helix in the central region.
  2. bGlobular: models with kinks in the central region.
  3. cUnstructured: models with an unfolded topology or missing C-terminal residues encompassing ARM-2.