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Figure 1 | Retrovirology

Figure 1

From: Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding

Figure 1

Rev sequences used for computational prediction of tertiary structures. A. Schematic representations of the reference EIAV R1 Rev165 and R1 deletion mutants, Rev∆HVR and Rev135. The residue numbers indicate N and C termini and boundaries of deleted regions. The locations of functional motifs are indicated: NES: nuclear export signal, ARM: arginine-rich motif, HVR: hypervariable region. B. Alignment of Rev165 and RevFDD, derived from the fetal donkey dermal cell-adapted Chinese strain EIAVFDD-10 [44]. Sequences shown to be non-essential for nuclear export activity (exon1 and HVR [26]) are underlined, while characterized functional motifs (NES, ARM-1, and ARM-2) are boxed.

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