Figure 1From: Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA bindingRev sequences used for computational prediction of tertiary structures. A. Schematic representations of the reference EIAV R1 Rev165 and R1 deletion mutants, Rev∆HVR and Rev135. The residue numbers indicate N and C termini and boundaries of deleted regions. The locations of functional motifs are indicated: NES: nuclear export signal, ARM: arginine-rich motif, HVR: hypervariable region. B. Alignment of Rev165 and RevFDD, derived from the fetal donkey dermal cell-adapted Chinese strain EIAVFDD-10 [44]. Sequences shown to be non-essential for nuclear export activity (exon1 and HVR [26]) are underlined, while characterized functional motifs (NES, ARM-1, and ARM-2) are boxed.Back to article page